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Expanding the Pool of Organs for Transplant
Heart transplantation does not adequately address the magnitude and severity of advanced heart failure (HF), a global public health concern that has the potential to reach epidemic proportions. While the gold standard for treating end-stage HF…
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FIRST LOOK: Novel Target Discovery Pipeline for Calcific Aortic Valve Disease
Aortic stenosis due to calcific aortic valve disease (CAVD) is the most prevalent valvular disorder and is on the rise as the population ages. Left untreated CAVD has a dismal prognosis, inevitably leading to death. Annually,…
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FIRST LOOK: Stratifying Exercise Dysfunction
Exercise dysfunction is highly prevalent across the global spectrum of medical diseases, and is a principal cause of morbidity and increased healthcare cost burden. Abnormalities in multiple organ systems often underlie exercise dysfunction. However, current methods…
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Understanding Why Exercise Works for Just About Everything
Centuries ago, the Greek physician Hippocrates noted that when the body is “unused and left idle, it becomes liable to disease, defective in growth, and ages quickly.” These observations—made without the benefit of the exhaustive medical…
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FIRST LOOK: Harnessing Endogenous Mechanisms of Programmed Gene Expression for Therapeutic Benefit in Cardiometabolic Disorders
Proximal mechanisms for programmatic control of gene expression exist that underlie the complex, distinct and at times disparate components of cardiometabolic health and dysfunction. Identifying such pathways offers new insights into physiologic and pathologic states, novel…
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FIRST LOOK: Signaling and Pulmonary Vascular Disease
Our laboratory has investigated the role of bone morphogenetic protein (BMP) and transforming growth factor β (TGF-β) signaling pathways in the pathogenesis of vascular disease. Loss-of-function mutations involving this pathway are implicated in several congenital vascular…
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FIRST LOOK: Atrial Fibrillation: Causal Basis and Personalized Risk Assessment
Cardiac arrhythmias are a leading cause of morbidity and sudden death, and collectively constitute a substantial public health problem. We are focused on understanding the causes of cardiac arrhythmias and applying discoveries to improve outcomes in…
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FIRST LOOK: A Novel Epigenetic Complex Implicated in Thoracic Aortic Aneurysm (TAA)
The Lindsay laboratory focuses on the clinical expression and molecular etiology of human thoracic aortic aneurysm (TAA). Aneurysm represents the anatomic expression of aortic organ failure with dilation and eventual tear; an event termed “dissection” associated…
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Allergan’s Patent Deal and the Plight of Patent System
It’s been nearly 3 months since Allergan announced their “deal” with the St. Regis Mohawk Tribe and the national reaction and fallout has resulted in many different opinions. To recap: the deal consists of two transactions:…
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IP Protection: Safeguarding your Research for Commercialization
The journey of taking a great new idea and advancing it to improving patient care can be long and often includes solving problems inventors have not previously faced. Understanding and navigating how the intellectual property (IP)…
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Found in Translation: Please allow me to introduce myself
Over the past decade or so there has been an accelerating shift in academic science towards translational research. This move has been quite overt, with the NIH establishing National Center for Advancing Translational Sciences (NCATS) in…
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Partners HealthCare raises $171 million to invest in early-stage life science companies
I am excited to announce that Partners HealthCare System has closed on $171.1 million in capital to invest in early-stage life sciences companies, which are a critical segment of the state’s innovation economy. The funds raised…
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Patent 101: Learn the importance of patents…and how to protect your invention.
What: In the United States, a patent gives the inventor an exclusive right to exclude others from making, using, selling, offering for sale, or importing the claimed invention. Many people unfamiliar with the patenting process mistakenly…
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Filling The Gap: Translating Your Research Via Disease Foundation Support
An energetic audience gathered on September 19th at The Brigham to attend the Partners Innovation Symposium Series in which the focus was “Filling The Gap: Translating Your Research Via Disease Foundation Support”. The session was focused…
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The Springboard Challenge: Making a Difference in NDD and NID
Partners HealthCare announced the Springboard Challenge planning grant awards at the World Neuroscience Innovation Forum in London earlier this year. In announcing the awards, we challenged the Forum’s participants to come up with a solution that…
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Artificial Intelligence: Transforming Patient Care!
Whether you like it or not, Artificial Intelligence (AI) is no longer an enigma lurking in the shadows. It’s here, for real, and manifest in our everyday lives. You don’t believe me? It’s true. When you…
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Moving up the diagnostic funnel
Towards acceptance of new diagnostic methodology Over the last two decades of the 20th century the future of diagnostics appeared very bright. By the start of the 21st century we would be deep into an era…
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A Call for Public Investment and Service in Technology Transfer
When I was young(er) and thinking about what I wanted to do with my life and what kind of education I would need, I knew that I did not want the product of my labor to…
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