Getting Great Science to Market

Innovator’s Commercialization Guide

July 23, 2021

Are you an innovator with ideas that you’d like to protect and commercialize? Do you imagine working with industry to commercialize an invention? Do you know who and how to contact the team at Mass General Brigham Innovation? Innovation recently launched a guide to help navigate the various paths to commercialization and how to contact…

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Rebuilding the Brain in Parkinson’s Disease

June 30, 2021

Gene and cell therapy at a crossroads After glimpsing the promise of gene and cell therapy, Mass General Brigham researchers are now enhancing the technology to drive new treatments for rare and common diseases Replacing defective genes or cells with healthy ones has been a goal of modern medicine for decades. And while that aspiration…

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‘Moving the Needle’ for Glioblastoma

June 30, 2021

Gene and cell therapy at a crossroads After glimpsing the promise of gene and cell therapy, Mass General Brigham researchers are now enhancing the technology to drive new treatments for rare and common diseases Replacing defective genes or cells with healthy ones has been a goal of modern medicine for decades. And while that aspiration…

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Toward Gene Therapies for Hearing Loss

June 30, 2021

Gene and cell therapy at a crossroads After glimpsing the promise of gene and cell therapy, Mass General Brigham researchers are now enhancing the technology to drive new treatments for rare and common diseases Replacing defective genes or cells with healthy ones has been a goal of modern medicine for decades. And while that aspiration…

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Driven to Solve Devastating Rare Diseases

June 30, 2021

Gene and cell therapy at a crossroads After glimpsing the promise of gene and cell therapy, Mass General Brigham researchers are now enhancing the technology to drive new treatments for rare and common diseases Replacing defective genes or cells with healthy ones has been a goal of modern medicine for decades. And while that aspiration…

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Lessening the Burden of Type 1 Diabetes with Innovative Cell Therapies

May 6, 2021

By: Manasi Sinha Jaiman, M.D., M.P.H., Vice President, Clinical Development Imagine an 18-year-old walking into my office. She is looking forward to graduation.  Feeling the thrill of receiving that college acceptance letter.  Planning gatherings with friends for summer before heading away to school.  Then I deliver the diagnosis – Type 1 diabetes (T1D):  That patient’s…

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Investigators at Brigham and Women’s Hospital take active role in ACTIV-4

December 3, 2020

The COVID-19 virus has taken over life as we know it, creating a novel environment for science in which collaboration is key and extraordinary speed is expected without sacrificing accuracy. Funded through Operation Warp Speed, the National Institutes of Health (NIH) launched the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership back in April.…

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Drug Delivery Directly to the Tumor

September 3, 2019

Historically, scientists have thought of cancer cells as a clone army—since they are all genetically identical, they are universally bad actors. “What we’ve learned since then is that they are more like special forces,” says David Ting, MD, Assistant Physician at the Mass General Cancer Center and Assistant Professor of Medicine at Harvard Medical School.…

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Digital Disease Management

Digital Disease Management

July 12, 2019

The need for better ways to manage chronic diseases is clear. According to the Centers for Disease Control, chronic diseases are the leading cause of death and disability and a leading driver of the nation’s $3.3 trillion in healthcare costs. While initially promising, telehealth—the use of telecommunications to enhance patient care and promote disease prevention—hasn’t…

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Innovators in Offices Getting Coffee

July 12, 2019

Innovation and entrepreneurship abound throughout Partners HealthCare, led by world-class investigators and research team members such as you, who work every day to turn ideas into solutions for patients and clinicians around the world. To further this spirit of invention and provide some practical commercialization advice and instruction from some of PHS’ most prolific inventors…

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Disseminating Medical Expertise to Areas that Need it Most

October 16, 2018

Replacing physicians has been cited as an aim of artificial-intelligence-based approaches to health care. Yet beyond the hype and hyperbole, there is a much more likely — and worthy — application of AI to medicine: infusing clinical expertise into regions where doctors are in short supply. A key case in point: the global shortage of…

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FIRST LOOK: Identification of Healthcare Risks in COPD Patients Using CT and X-ray Images

October 16, 2018

Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory conditions that affects more than 22 million Americans; it has climbed to be the third leading cause of death and accounts for $32 billion in associated healthcare cost. https://www.youtube.com/watch?v=lLkXqGk8bIM COPD remains underdiagnosed, and its associated comorbidities include cardiovascular disease, musculoskeletal disorders, and lung…

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CRISPR and ZFN, Two Promising Gene-Editing Platforms

October 2, 2018

Though the underlying mechanism is said to have been initially discovered in 1987, the potential to use CRISPR/Cas9 (“CRISPR”) as a gene editing therapy has recently enthralled the media since its first application in 2013[1]; touting its “blockbuster” potential to “revolutionize” modern medicine as we know it. While the application of this underlying biological mechanism…

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Getting Back to Face Time: AI Tools that Help Reduce Physicians’ Computer Use

September 18, 2018

Just as computers have propelled major advances in modern medicine, their presence has also become a significant burden. That’s because the amount of time physicians now spend on the computer — reviewing clinical data and completing required documentation in electronic health records (EHRs) — has soared. It is estimated that physicians spend roughly half of…

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Minimizing the Threats of Antimicrobial Resistance and Infections Associated with Antibiotic Use

September 4, 2018

The introduction of effective antibiotics in the 1940s ushered in an era of optimism with rapid declines in deaths due to infections. Since that time, however, antibiotic resistance has emerged rapidly, and too few antibiotics are making it through the development pipeline. That means once curable infections could soon become more virulent and even untreatable.…

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FIRST LOOK: Surgical Fingerprints: Real-time Analysis of Intraoperative Events

August 23, 2018

Intraoperative adverse events (IAEs), such as bowel/vascular injury, are estimated to occur in 2% of operations. IAEs can exact a toll on patient quality of life and costs, with average admission charges estimated to be 41% higher for patients who experience IAEs. Up to two-thirds of surgical errors occur intraoperatively, and 86% of these are…

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Harnessing the Power of Digital Pathology

August 16, 2018

Through its decades-long practice of digitizing clinical images, radiology is providing an early proving ground for machine learning-based approaches for disease detection, diagnosis, and prognosis. With a vast, rich pool of radiological images, researchers have access to the raw material needed to develop and hone new disease-detection algorithms, which are helping to drive the AI…

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Bringing “Smart” Machines to Medicine

August 1, 2018

Self-driving cars are poised to disrupt the transportation industry, and there is a similar revolution underway in health care. This effort seeks to engineer a new generation of “smart” medical equipment that melds scanning with interpretation, monitoring with treatment, and merges data from disparate devices into a common, readily interpretable stream. The goal: to help…

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