Getting Great Science to Market

Copyright 101: learn how to protect your creative works.

July 24, 2018

What: Copyrights protect original works of authorship fixed in a tangible medium of expression and this really speaks to what kinds of things are “eligible” for copyright protection. But to put it more simply, copyrights protect the expression of ideas. If we want to have a firm grasp of what copyrights really are, we’re going…

Read More

Reading the Tea Leaves of Cancer Immunotherapy

July 19, 2018

The immune system protects the body from a host of foreign invaders. Over the last few years, therapies that leverage these defenses to fight cancer — so-called cancer immunotherapies — have yielded impressive outcomes in combating some forms of the disease. Yet as promising as these therapies are, they currently help only a small subset…

Read More

FIRST LOOK: bloodTyper: Blood Group Typing using Next Generation Sequencing

July 19, 2018

Blood transfusion is one of the most common therapies administered in US hospitals, but sensitization to red blood cell (RBC) and platelet (PLT) antigens can lead to serious complications in prenatal medicine and transfusion. Although there are over 300 known RBC and 33 PLT antigens, current testing only includes matching the patient and donor for…

Read More

FIRST LOOK: Leveraging Machine Learning for Personalized Cancer Treatments

July 10, 2018

It is not obvious how decades of hard won biological knowledge can be incorporated into building machine learning algorithms for predicting how a drug will affect a patient. We study this problem from theoretical, computational, and practical angles. Click here to watch Dr. Craft’s First Look presentation. Our computational studies provide strong evidence that incorporating…

Read More

From Innovation to Commercialization – Bridging the Gap

June 21, 2018

In a world where science, technology, and innovation run parallel to the entrepreneurial spirit, a bridge is often needed to connect expertise, knowledge and wisdom to the lifesaving inventions that patients need most. That’s why we launched the BRIDGES blog. Launched in December 2017, BRIDGES is a collaborative resource where Innovation staff, technology experts, investors,…

Read More

Collaboration Agreement Primer: Basics for Busy PIs

June 21, 2018

As a busy PI conducting research, have you ever wondered why your institution asks you to complete certain agreements related to your research and what do they all mean. In a recent article in Nature Biotechnology, Colm Lawler, PhD, Senior Licensing Manager and his co-authors attempt to provide a guide for navigating the alphabet soup…

Read More

BWH ED Redesign to Help Cancer Patients and Researchers

June 21, 2018

A unique challenge of the emergency department (ED) at Brigham and Women’s Hospital has become the catalyst for a new project designed to improve emergency care for oncology patients and develop new technologies for the ED. BWH is about to launch a four-year, $52 million renovation and expansion project. Approximately two-thirds of that funding will…

Read More

Can Personal Devices Improve Your Health?

June 19, 2018

Digital devices permeate our lives. For most of our waking hours, we sport mini-computers strapped to our wrists or tucked into a pocket. We rely on these gadgets for an ever-expanding array of tasks, and without them (or their sufficiently juiced batteries), modern life can come to a screeching halt. It seems almost natural, then,…

Read More

FIRST LOOK: Leveraging AI and biological networks to functionally interpret vast genetic datasets

June 12, 2018

With the unprecedented ability to sequence genomes and to genotype millions of patients’ functional interpretation of genetic data is now one of the major bottlenecks in science and healthcare. This is a key constraint on our efforts toward biological understanding and patient-specific therapeutic intervention in human diseases. In parallel, high throughput technologies in transcriptomics and…

Read More

FIRST LOOK: Mass Spectrometry Imaging for Surgical Pathology and Oncology

June 12, 2018

Mass spectrometry provides multiple options for the direct biomolecular characterization of tissue to support clinical decision-making and provides significant insight in the development of drugs targeting tumors of the central nervous system. Using an array of mass spectrometry (MS) applications, we rapidly analyze tumor markers ranging from small metabolites to proteins from surgical tissue for…

Read More

A Picture is Worth a Thousand Words

June 4, 2018

In medicine, an image on a computer screen is more than just a picture; it is millions, even billions of data points that can be systematically scrutinized and mined for connections to health and disease. Understanding how these data points vary within and between images — and patients — stretches the limits of human cognition.…

Read More

FIRST LOOK: Using Residual Convolutional Neural Networks to Improve Treatment of Brain Tumors

May 23, 2018

Gliomas are the most common primary brain tumor in adults and the cure remains elusive. Certain pathological biomarkers including the mutation status of isocitrate dehydrogenase (IDH) have significant implications on the benefits of aggressive surgical resection, response to treatment and overall prognosis. Tissue sampling via biopsy or surgical resection has been required to elucidate biomarker…

Read More

AI at the Bedside

May 15, 2018

As medicine has grown in complexity, the amount of data a single patient can generate — even during a brief hospital stay — has skyrocketed. This big data challenge is reflected in the array of clinical measurements that clinicians can gather at patients’ bedsides, such as blood pressure readings, electrocardiograms (ECGs), and electroencephalograms (EEGs). For…

Read More

FIRST LOOK: Mobile Apps: Bridging the Mental Health Treatment Gap

May 15, 2018

Barriers to accessing evidence-based mental health treatment include a lack of available providers, high costs, and stigma. Technology-delivered interventions, such as Smartphone apps, present a promising avenue for reducing barriers. To this end, in partnership with Telefónica Alpha, the Massachusetts General Hospital (MGH) OCD and Related Disorders program is developing and pilot testing a cognitive…

Read More

FIRST LOOK: A Machine Learning Algorithm to Reduce Costs and Increase Quality

May 15, 2018

Diagnostic tests are the lynchpin of medical care. From a health point of view, bad testing can lead to missed or incorrect diagnoses. From a cost point of view, bad testing is a major source of unneeded expenditures—the majority of the care labeled as “low value” by the Choosing Wisely campaign were diagnostic tests. Click…

Read More

Sponsored Research Agreements: Negotiating with a Non-Profit Research Institution

May 15, 2018

Unlike more traditional business transactions between two or more for-profit companies, research and development between a for-profit company and a non-profit institution or academic research organization comes with its own rule book. The intersection of two bodies of legislation dictates the behavior of such institutions when engaging in R&D activities on behalf of a for-profit…

Read More

FIRST LOOK: Targeting Vascular Calcification to Prevent Cardiovascular Disease

April 30, 2018

Vascular calcification is the abnormal deposition of calcium phosphate crystals within the blood vessel wall, is one of the strongest risk factors for cardiovascular disease, and predicts clinical events such as myocardial infarction and stroke.  The following approaches are being utilized in our laboratory to target vascular calcification: Human Genetics: Approximately 50% of cardiovascular disease…

Read More

Nanotechnologies for Cardiac Diagnosis and Treatment

April 30, 2018

Weighing in at a little less than three-quarters of a pound, the heart has the formidable task of pumping oxygen- and nutrient-rich blood through the 60,000-mile highway of blood vessels to all the tissues of the body. Unfortunately, more than 15 million Americans suffer from coronary artery disease, which occurs when the arteries that carry…

Read More