Getting Great Science to Market

Can Personal Devices Improve Your Health?

June 19, 2018

Digital devices permeate our lives. For most of our waking hours, we sport mini-computers strapped to our wrists or tucked into a pocket. We rely on these gadgets for an ever-expanding array of tasks, and without them (or their sufficiently juiced batteries), modern life can come to a screeching halt. It seems almost natural, then,…

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FIRST LOOK: Leveraging AI and biological networks to functionally interpret vast genetic datasets

June 12, 2018

With the unprecedented ability to sequence genomes and to genotype millions of patients’ functional interpretation of genetic data is now one of the major bottlenecks in science and healthcare. This is a key constraint on our efforts toward biological understanding and patient-specific therapeutic intervention in human diseases. In parallel, high throughput technologies in transcriptomics and…

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FIRST LOOK: Mass Spectrometry Imaging for Surgical Pathology and Oncology

June 12, 2018

Mass spectrometry provides multiple options for the direct biomolecular characterization of tissue to support clinical decision-making and provides significant insight in the development of drugs targeting tumors of the central nervous system. Using an array of mass spectrometry (MS) applications, we rapidly analyze tumor markers ranging from small metabolites to proteins from surgical tissue for…

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A Picture is Worth a Thousand Words

June 4, 2018

In medicine, an image on a computer screen is more than just a picture; it is millions, even billions of data points that can be systematically scrutinized and mined for connections to health and disease. Understanding how these data points vary within and between images — and patients — stretches the limits of human cognition.…

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FIRST LOOK: Using Residual Convolutional Neural Networks to Improve Treatment of Brain Tumors

May 23, 2018

Gliomas are the most common primary brain tumor in adults and the cure remains elusive. Certain pathological biomarkers including the mutation status of isocitrate dehydrogenase (IDH) have significant implications on the benefits of aggressive surgical resection, response to treatment and overall prognosis. Tissue sampling via biopsy or surgical resection has been required to elucidate biomarker…

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AI at the Bedside

May 15, 2018

As medicine has grown in complexity, the amount of data a single patient can generate — even during a brief hospital stay — has skyrocketed. This big data challenge is reflected in the array of clinical measurements that clinicians can gather at patients’ bedsides, such as blood pressure readings, electrocardiograms (ECGs), and electroencephalograms (EEGs). For…

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FIRST LOOK: Mobile Apps: Bridging the Mental Health Treatment Gap

May 15, 2018

Barriers to accessing evidence-based mental health treatment include a lack of available providers, high costs, and stigma. Technology-delivered interventions, such as Smartphone apps, present a promising avenue for reducing barriers. To this end, in partnership with Telefónica Alpha, the Massachusetts General Hospital (MGH) OCD and Related Disorders program is developing and pilot testing a cognitive…

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FIRST LOOK: A Machine Learning Algorithm to Reduce Costs and Increase Quality

May 15, 2018

Diagnostic tests are the lynchpin of medical care. From a health point of view, bad testing can lead to missed or incorrect diagnoses. From a cost point of view, bad testing is a major source of unneeded expenditures—the majority of the care labeled as “low value” by the Choosing Wisely campaign were diagnostic tests. Click…

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Sponsored Research Agreements: Negotiating with a Non-Profit Research Institution

May 15, 2018

Unlike more traditional business transactions between two or more for-profit companies, research and development between a for-profit company and a non-profit institution or academic research organization comes with its own rule book. The intersection of two bodies of legislation dictates the behavior of such institutions when engaging in R&D activities on behalf of a for-profit…

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FIRST LOOK: Targeting Vascular Calcification to Prevent Cardiovascular Disease

April 30, 2018

Vascular calcification is the abnormal deposition of calcium phosphate crystals within the blood vessel wall, is one of the strongest risk factors for cardiovascular disease, and predicts clinical events such as myocardial infarction and stroke.  The following approaches are being utilized in our laboratory to target vascular calcification: Human Genetics: Approximately 50% of cardiovascular disease…

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Nanotechnologies for Cardiac Diagnosis and Treatment

April 30, 2018

Weighing in at a little less than three-quarters of a pound, the heart has the formidable task of pumping oxygen- and nutrient-rich blood through the 60,000-mile highway of blood vessels to all the tissues of the body. Unfortunately, more than 15 million Americans suffer from coronary artery disease, which occurs when the arteries that carry…

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Finding Cancer Therapies Without Cardiotoxicity

April 30, 2018

Lasting cardiac damage from cancer therapy can be devastating. Thanks to powerful new therapies, many people are surviving cancers that were once believed to be fatal. We are now seeing, however, that the off-target effects of these cancer therapies can have deadly repercussions, such as heart failure, cardiac arrhythmia, thrombosis, heart attack, severe hypertension, Q-T…

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Navigating the Alphabet Soup of Agreements

March 22, 2018

As a busy PI conducting research, have you ever wondered why your institution asks you to complete certain agreements related to your research and what do they all mean. In a recent article in Nature Biotechnology, Dr. Colm Lawler, Senior Licensing Manager, from Partners Innovation and his co-authors from NYU and SUNY Upstate Medical, attempt…

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Industry Insights: Positioning Your Research to a Commercial Partner

March 22, 2018

Click here to watch the full length video. Much of the research conducted at our hospitals is applied to finding new treatments for some of the world’s most intractable diseases.  Collaborating with an industry partner on this research can be essential to keeping the research focused on a commercially viable path that leads to development…

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FIRST LOOK: Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

March 22, 2018

Both genetic and lifestyle factors are key drivers of coronary artery disease, a complex disorder that is the leading cause of death worldwide. Long recognized to be heritable, genomewide association analyses have identified more than 50 independent variants robustly associated with risk of coronary disease. These risk alleles, when aggregated into a polygenic risk score,…

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Breaking the Code: Diagnostic and Therapeutic Potential of RNA

March 13, 2018

Ribonucleic acid, or RNA, is one of the three major biological macromolecules that are, along with DNA and proteins, essential for all known forms of life. Recently, types of RNA called microRNAs (miRNA) and long-non-coding RNAs (lncRNAs) have been found to play important roles in gene regulation, capturing international scientific attention for their potential as…

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FIRST LOOK: Exercise Prescription to Improve Cardiovascular and Cancer Outcomes in Cancer Survivors

March 13, 2018

Exercise prescription upon completion of cancer therapies could improve fitness, as well as cardiovascular and cancer outcomes for select cancer survivors. Given the growing population of cancer survivors, exercise prescription has tremendous clinical and commercial potential. Advances in cancer care have achieved significant improvements in cancer survival, such that the population of cancer survivors in…

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Less is More: Minimalist Mitral Valve Repair

March 7, 2018

In the last decade, there has been a revolution in transcatheter therapies for structural heart disease. The most widely embraced, transcatheter aortic valve replacement (TAVR), was originally intended for patients with aortic stenosis, in whom surgery was considered prohibitive, but it has now been utilized as an excellent alternative to surgical aortic valve replacement in…

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