Getting Great Science to Market
Navigating Healthcare IT: Winning Strategies to Commercialize Your HIT Invention
The opportunities and challenges of commercializing Healthcare Information Technology, or HIT, are different from those in licensing other patent-protected technologies. The third Symposium Series session, held on December 7th, took up that challenge and focused on the many activities Partners is engaged in to facilitate development of cutting edge HIT tools to support patient care.…
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FIRST LOOK: New Approaches to Controlling Stem Cell Fate
Embryonic stem cells and induced pluripotent stem cells, which can be propagated indefinitely in culture in an undifferentiated state or induced to differentiate into every cell type in the adult body, holds promise for regenerative medicine. Proper execution of these distinct but developmentally relevant programs requires precise tuning of gene expression by transcription factors. Indeed,…
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Quantitative Molecular Imaging for Cardiovascular Phenotypes
More than 17 million deaths worldwide were attributed to heart disease in 2016, and cardiovascular ailments persistently remain one of the biggest causes of hospital admissions in the United States. Cardiovascular disease also accounts for more healthcare costs than any other chronic illness, and is responsible for one out of every three deaths, on average.…
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FIRST LOOK: Using Zebrafish to Understand and Harness Cardiac Regeneration
The adult mammalian heart lacks any appreciable capacity to regenerate ischemia-damaged muscle. By comparison, injured zebrafish hearts mount an impressive regenerative response driven by robust myocardial proliferation. My laboratory’s research program is driven by the simple assumption that a complete understanding of cardiomyocyte proliferation regulatory mechanisms in zebrafish could be leveraged to promote heart regeneration…
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Targeting Inflammation in Cardiovascular Disease
Inflammation is the body’s natural way of protecting itself from harm. When fatty, cholesterol-rich plaque accumulates within the arterial walls, the immune system perceives it to be a foreign invader and sends white blood cells to attack, resulting in chronic low-grade arterial inflammation. It’s now believed that heart attacks and stroke are linked to this…
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Found in Translation: Academic Intellectual Property FAQ
For this post I want to build upon a great introduction to the world of patents that my colleague Nate Valverde, J.D. provided in his excellent article: Patent 101: Learn the importance of patents…and how to protect your invention.here Many academic researchers have specific questions as they seek to translate their basic science discoveries into…
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FIRST LOOK: Aging and the Activin Type II Receptor Pathway: A New Target for Heart Failure Therapy?
Heart failure (HF) represents a leading cause of morbidity and mortality in the elderly. Despite the strong association between advanced age and HF, the underlying molecular mechanisms by which the aging process predisposes older adults to HF remain unclear. To that end, our group is exploring biological systems that potentially link aging to HF pathophysiology…
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Expanding the Pool of Organs for Transplant
Heart transplantation does not adequately address the magnitude and severity of advanced heart failure (HF), a global public health concern that has the potential to reach epidemic proportions. While the gold standard for treating end-stage HF continues to be heart transplantation, there are simply not enough donor hearts available (about 2,000) for the more than…
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FIRST LOOK: Novel Target Discovery Pipeline for Calcific Aortic Valve Disease
Aortic stenosis due to calcific aortic valve disease (CAVD) is the most prevalent valvular disorder and is on the rise as the population ages. Left untreated CAVD has a dismal prognosis, inevitably leading to death. Annually, in the US alone, 80,000 patients progress to severe CAVD, requiring aortic valve intervention and at a cost of…
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FIRST LOOK: Stratifying Exercise Dysfunction
Exercise dysfunction is highly prevalent across the global spectrum of medical diseases, and is a principal cause of morbidity and increased healthcare cost burden. Abnormalities in multiple organ systems often underlie exercise dysfunction. However, current methods for analyzing exercise test results often rely on a narrow subset of variables involving a single organ system. This…
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Understanding Why Exercise Works for Just About Everything
Centuries ago, the Greek physician Hippocrates noted that when the body is “unused and left idle, it becomes liable to disease, defective in growth, and ages quickly.” These observations—made without the benefit of the exhaustive medical research and detailed studies that we have today—are just as valid now as they were then. Exercise is a…
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FIRST LOOK: Harnessing Endogenous Mechanisms of Programmed Gene Expression for Therapeutic Benefit in Cardiometabolic Disorders
Proximal mechanisms for programmatic control of gene expression exist that underlie the complex, distinct and at times disparate components of cardiometabolic health and dysfunction. Identifying such pathways offers new insights into physiologic and pathologic states, novel treatment strategies and a more rational basis for therapies based on endogenous biology. Through this focus, we identified how…
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FIRST LOOK: Signaling and Pulmonary Vascular Disease
Our laboratory has investigated the role of bone morphogenetic protein (BMP) and transforming growth factor β (TGF-β) signaling pathways in the pathogenesis of vascular disease. Loss-of-function mutations involving this pathway are implicated in several congenital vascular syndromes including heritable pulmonary arterial hypertension (HPAH) and hereditary hemorrhagic telangiectasia (HHT) syndrome. A physiologic balance of BMP, Activin,…
Read MoreFunctionally Understanding the Microbiome
This is the second article in a series about research related to the human microbiome at Partners’ academic institutions. We talk to Alessio Fasano, MD, Director, Mucosal Immunology and Biology Research Center, MGH. In the past decade, technological advances have shown that what we thought we knew about the human microbiome was only the tip…
Read MoreInflammation and Disease: Brigham Breakthrough Rocks CV Community
A new analysis seeks to answer the question of which patients are likely to gain the greatest cardiovascular benefit when treated with the anti-inflammatory agent canakinumab. At the 2017 American Heart Association Scientific Sessions, Paul Ridker, MD, director of the BWH Center for Cardiovascular Disease Prevention presented the groundbreaking results of his 10,000+ patient study…
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FIRST LOOK: Atrial Fibrillation: Causal Basis and Personalized Risk Assessment
Cardiac arrhythmias are a leading cause of morbidity and sudden death, and collectively constitute a substantial public health problem. We are focused on understanding the causes of cardiac arrhythmias and applying discoveries to improve outcomes in patients with these conditions. Our research spans disciplines involving human genetics, mobile health technology, and clinical trials. A major…
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FIRST LOOK: A Novel Epigenetic Complex Implicated in Thoracic Aortic Aneurysm (TAA)
The Lindsay laboratory focuses on the clinical expression and molecular etiology of human thoracic aortic aneurysm (TAA). Aneurysm represents the anatomic expression of aortic organ failure with dilation and eventual tear; an event termed “dissection” associated with high mortality. In our research we use human and murine genetics as well as animal modeling to investigate…
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Allergan’s Patent Deal and the Plight of Patent System
It’s been nearly 3 months since Allergan announced their “deal” with the St. Regis Mohawk Tribe and the national reaction and fallout has resulted in many different opinions. To recap: the deal consists of two transactions: in the first, Allergan assigned its orange book(1)The Orange Book is a catalogue of issued patents that cover FDA…
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