Meet the Team
Driving CRISPR to the Clinic
In the short time since the emergence of CRISPR gene editing technology, Keith Joung, MD, PhD has been impressed with all the research applications that have been developed to harness its potential. “It is remarkable how it’s been used to build cell lines and model organisms, gain new insights into more of the mechanisms of…
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Calum MacRae, MD, PhD: One Brave Heart
Musing over the proposal that netted him a $75 million “One Brave Idea” prize from the American Heart Association, Calum MacRae, MD, PhD recognizing the many applicants for the grant, credits good luck and strong collaborations over ingenuity. “I think the funders were brave to give us the money.” Nevertheless, MacRae, chief of cardiovascular medicine…
Read MoreConnecting Care
Keeping track of personal health has become an industry. From off-the-shelf fitness trackers and mobile apps to systematic efforts like the quantified-self movement, personal health monitoring is virtually ubiquitous. Yet long before it became commonplace, Partners Connected Health sought to change the approach to health care delivery: from provider-driven treatment to patient-centered care. Launched twenty…
Read MoreGary Ruvkun, PhD: MicroRNA, Cancer and Heart Disease
As a child growing up in the Sputnik era, Gary Ruvkun, PhD explored the night skies through the lens of a telescope and, as he learned more astronomy, realized with fascination that the universe has secret layers. “When you do visible astronomy, you see one set of stars. When you do X-ray as-tronomy, you see…
Read MoreStephen Elledge, PhD Wins Lasker Award
A profile of BWH's Lasker Award winning Stephen Elledge, PhD and a look at his work on eukaryotic DNA damage response, as well as a new focus on the mechanisms of cell cycle control. In some ways, the eukaryotic cell is akin to a miniature city: Mitochondrial energy plants power the cell; lysosomes act as…
Read MoreInnovator Profile: Innovation's Building Blocks
A profile of Charles Serhan, PhD, DSc, a mastermind behind the inflammation pro-resolving therapies known as resolvins and the specialized pro-resolving mediators (SPM). Charles Serhan, PhD, DSc, a mastermind behind the inflammation pro-resolving therapies known as resolvins and the specialized pro-resolving mediators (SPM), is no stranger to the celebrity side of science. Coming of age…
Read MoreThe Austen Family: Lifetimes of Innovation and Healing
Highlighting the Austens, a family whose innovations have revolutionized medical care and clinical research since the 1950s. For a fortunate few, vision isn't just one of the five senses. It's the predominant sense; it's a way of life. Vision is imagining a solution, already attained: What does it look like? How does it work? Where…
Read MoreInvestigator Profile: Warren Zapol, MD and Nitric Oxide
A profile of Warren Zapol, MD, the Emeritus Anesthetist-in-Chief and Reginald Jenney Professor of Anesthesia at Harvard Medical School In the 25 years since discovering a life-saving therapy consisting of breathing low levels of the gas nitric oxide—which is still the only selective inhaled pulmonary vasodilator—Massachusetts General Hospital (MGH) anesthesiologist Warren M. Zapol, MD, and…
Read MoreDieter Manstein MD, PhD: Innovative Procedures Get Under Your Skin
A profile of Dieter Manstein, MD, PhD, and his great achievements in Dermatology: fractional photothermolysis and selective Cryolipolysis®. Dieter Manstein, MD, PhD turned a two-year research project into a career of developing major dermatology innovations to treat scars, skin aging, and noninvasively remove fat. In November of 1998, he immigrated to Boston, from Germany, where…
Read MoreRichard Lee, MD: Fighting Aging One Beat at a Time
A look at Richard Lee, MD's research and discovery of GDF11 aimed at aging in the heart. When two prominent researchers meet for coffee, you never know what breakthrough medical advances might arise. Five years ago, Richard Lee, MD, a cardiologist at Brigham and Women's Hospital, and his good friend Harvard regenerative biologist Amy Wagers,…
Read MoreTechnology Profile: Studies Awakening New Understanding of Anesthesia
Emery Brown, MD, PhD, and Patrick Purdon, PhD give insight into their research and use of a new neuroscience-based approach to researching anesthesia. A few years ago, Emery Brown, MD, PhD, realized that something seemingly obvious was missing from the way anesthesiologists historically had approached their research since drugs were first used to induce general…
Read MorePrinted from https://innovationblog.partners.org/driving-crispr-to-the-clinic · Published 21 Feb 2019
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